Project Fully-Integrated CMOS Biochip Arrays for Multicolor Biomolecular Diagonistics
(Supplemental Funding)
(Supplemental Funding)
Principal Investigators Ken Shepard (Columbia University)
Rasti Levicky (Columbia University)
Ginger Chew (Columbia University)
Rasti Levicky (Columbia University)
Ginger Chew (Columbia University)
Student
Year 2007.1-2007.12
Abstract The proposed effort will develop fundamentals and technology of multiplexed, CMOS-based sensors for biomolecular (DNA and protein) fluorescence-based measurement and detection. Guiding principles include leveraging of economies of scale to provide low-cost devices; optimizing device self-sufficiency and miniaturization to afford maximum portability; developing parallelized designs for detection of multiple target analytes; enabling sensor-level circuits for detection, calibration, and control; and optimizing dynamic range, sensitivity, and speed of detection. Applications include gene expression profiling to connect genetic information to cellular function and response, pathogen detection and identification, classification of diseases and biological cells, forensics, environmental testing/monitoring, and genotyping (e.g. to guide medical treatment). Extensive field studies in the detection of allergens that cause asthma in children will be done as part of this work.
Report Final Report
Publications Included in the final report.
